The Effects of HPA Axis Genetic Variation and Early Life Stress on Cortisol Levels in Preschool Age Children and on Amygdala and Hippocampus Volumes, Reactivity, and Connectivity at School Age
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منابع مشابه
Paeoniflorin regulates the hypothalamic-pituitary-adrenal axis negative feedback in a rat model of post-traumatic stress disorder
Objective(s): To investigate the effects of paeoniflorin (PEF) on the hypothalamic-pituitary-adrenal (HPA) axis feedback function of post-traumatic stress disorder (PTSD). cSingle-prolonged stress (SPS) was used to establish a PTSD-like rat model. The contents of plasma corticosterone (CORT), adrenocorticotropin hormone (ACTH) and cortic...
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Accumulating evidence suggests a role for stress exposure, particularly during early life, and for variation in genes involved in stress response pathways in neural responsivity to emotional stimuli. Understanding how individual differences in these factors predict differences in emotional responsivity may be important for understanding both normative emotional development and for understanding...
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Although childhood is connected with high neuroplasticity changes, but because of the immaturity of the neural and cognitive systems, it is ready to grow developmental deviations and future susceptibility for neuropsychological disorders. Young children face cognitive, emotional, and linguistic limits that may lead them more vulnerable to post-traumatic stress disorder (PTSD). PTSD prevalence d...
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Neonatal pain-related stress is associated with elevated salivary cortisol levels to age 18 months in children born very preterm, compared to full-term, suggesting early programming effects. Importantly, interactions between immune/inflammatory and neuroendocrine systems may underlie programming effects. We examined whether cortisol changes persist to school age, and if common genetic variants ...
متن کاملAlterations in stress cortisol reactivity in depressed preschoolers relative to psychiatric and no-disorder comparison groups.
BACKGROUND Despite the robust and widely replicated finding of elevated hypothalamic-pituitary-adrenal (HPA) axis reactivity in depressed adults, studies of depressed children have yielded ambiguous findings. Animal models of early depression and studies of children experiencing early psychosocial deprivation have suggested that alterations in HPA axis reactivity are evident in early "depressiv...
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